The Twilight Zone between Protein Order and Disorder
نویسندگان
چکیده
منابع مشابه
Combining predictors of natively unfolded proteins to detect a twilight zone between order and disorder in generic datasets
Natively unfolded proteins lack a well defined three dimensional structure but have important biological functions, suggesting a re-assignment of the structure-function paradigm. Many proteins have amino acidic compositions compatible both with the folded and unfolded status, and belong to a twilight zone between order and disorder. This makes difficult a dichotomic classification of protein se...
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Sequence alignments unambiguously distinguish between protein pairs of similar and non-similar structure when the pairwise sequence identity is high (>40% for long alignments). The signal gets blurred in the twilight zone of 20-35% sequence identity. Here, more than a million sequence alignments were analysed between protein pairs of known structures to re-define a line distinguishing between t...
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Structural class characterizes the overall folding type of a protein or its domain. This paper develops an accurate method for in silico prediction of structural classes from low homology (twilight zone) protein sequences. The proposed LLSC-PRED method applies linear logistic regression classifier and a custom-designed, feature-based sequence representation to provide predictions. The main adva...
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To students of causality, the writings of William Cochran provide an excellent and intriguing vantage point for studying how statistics, lacking the necessary mathematical tools, managed nevertheless to cope with increasing demands for policy evaluation from observational studies. Cochran met this challenge in the years 1955-1980, when statistics was preparing for a profound, albeit tortuous tr...
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Sequence alignment of proteins and nucleic acids is a routine task in bioinformatics. Although the comparison of complete peptides, genes or genomes can be undertaken with a great variety of tools, the alignment of short DNA sequences and motifs entails pitfalls that have not been fully addressed yet. Here we confront the structural superposition of transcription factors with the sequence align...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2008
ISSN: 0006-3495
DOI: 10.1529/biophysj.108.131151